This report is generated by Quarto on June 10, 2025



Introduction

This report demonstrates results of the conducted analysis for proteomics at CASZ1.



Minor allele frequency of variants

Figure 1. Allele frequency of the variants

Figure 1. Allele frequency of the variants



Variants annotation plot

Figure 2. Number and annotation of the variants in each gene

Figure 2. Number and annotation of the variants in each gene



Discriptive statistics

Minimum allele count (AC) is set to 5 . Given 13447 samples, variants with AC below 5 and above 13442 are removed., , , Of 233 variants, 134 left with minor allele count > 5 for building haplotypes., , , Merged data comprised 134 variants, 149 traits, and 13 covariates.,



Haplotype plot

Haplotype variants

Figure 3. Alleles distribution across haplotypes

Figure 3. Alleles distribution across haplotypes



Haplotype tagging variants

Figure 4. Haplotypes narrowed by varied variants

Figure 4. Haplotypes narrowed by varied variants



Associations with proteomics

Heatmap plot

Figure 5. Heatmap plot of the associations coefficients

Figure 5. Heatmap plot of the associations coefficients



Table of results



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